Detalles de la búsqueda
1.
Efficacy and safety of MAS825 (anti-IL-1ß/IL-18) in COVID-19 patients with pneumonia and impaired respiratory function.
Clin Exp Immunol;
213(3): 265-275, 2023 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37338154
2.
Preclinical pharmacokinetics and metabolism of MAK683, a clinical stage selective oral embryonic ectoderm development (EED) inhibitor for cancer treatment.
Xenobiotica;
52(1): 65-78, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34761729
3.
Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived ß 2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies.
J Pharmacol Exp Ther;
369(2): 188-199, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30819762
4.
Structure-Guided Elaboration of a Fragment-Like Hit into an Orally Efficacious Leukotriene A4 Hydrolase Inhibitor.
J Med Chem;
67(6): 5093-5108, 2024 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38476002
5.
Fixing clearance as early as lead optimization using high throughput in vitro incubations in combination with exact mass detection and automatic structure elucidation of metabolites.
Drug Discov Today Technol;
10(1): e191-8, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24175349
6.
Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase.
J Med Chem;
66(23): 16410-16425, 2023 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38015154
7.
Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.
J Med Chem;
65(12): 8345-8379, 2022 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-35500094
8.
Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.
J Med Chem;
65(5): 4350-4366, 2022 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35195996
9.
Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J Med Chem;
65(7): 5317-5333, 2022 04 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35352560
10.
Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4.
J Med Chem;
63(21): 12542-12573, 2020 11 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32930584
11.
New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse.
ACS Med Chem Lett;
10(12): 1655-1660, 2019 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31857842
12.
FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer.
Mol Cancer Ther;
18(12): 2194-2206, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31409633
13.
Cytostar-T plates--a valid alternative for microplate scintillation counting of low radioactivity in combination with high-performance liquid chromatography in drug metabolism studies?
J Chromatogr A;
1157(1-2): 65-72, 2007 Jul 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-17466316
14.
Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach.
ACS Med Chem Lett;
7(8): 735-40, 2016 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27563395
15.
Targeted inhibition of the COP9 signalosome for treatment of cancer.
Nat Commun;
7: 13166, 2016 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-27774986
16.
SAR and pH stability of cyano-substituted epothilones.
Org Lett;
4(22): 3815-8, 2002 Oct 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-12599466
17.
Characterization of cytotoxic and genotoxic effects of different compounds in CHO K5 cells with the comet assay (single-cell gel electrophoresis assay).
Mutat Res;
537(2): 151-68, 2003 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-12787820
18.
N-Oxidation of Epothilone A-C and O-Acyl Rearrangement to C-19- and C-21-Substituted Epothilones.
Angew Chem Int Ed Engl;
38(13-14): 1971-1974, 1999 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34182693
19.
Comparison of a two-dimensional liquid chromatography/mass spectrometry approach with a chip-based nanoelectrospray device for structural elucidation of metabolites in a human ADME study using a quadrupole time-of-flight mass spectrometer.
Rapid Commun Mass Spectrom;
21(6): 937-44, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17295360
20.
Two-dimensional liquid chromatography/mass spectrometry set-up for structural elucidation of metabolites in complex biological matrices.
Rapid Commun Mass Spectrom;
21(6): 961-70, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17299833